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1.

Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity.

Jais, Alexander; Solas, Maite; Backes, Heiko; Chaurasia, Bhagirath; Kleinridders, André; Theurich, Sebastian; Mauer, Jan; Steculorum, Sophie M; Hampel, Brigitte; Goldau, Julia; Alber, Jens; Förster, Carola Y; Eming, Sabine A; Schwaninger, Markus; Ferrara, Napoleone; Karsenty, Gerard; Brüning, Jens C.

Cell; 165(4): 882-95, 2016 May 05.

Artículo en Inglés | MEDLINE | ID: mdl-27133169

2.

AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue.

Steculorum, Sophie M; Ruud, Johan; Karakasilioti, Ismene; Backes, Heiko; Engström Ruud, Linda; Timper, Katharina; Hess, Martin E; Tsaousidou, Eva; Mauer, Jan; Vogt, Merly C; Paeger, Lars; Bremser, Stephan; Klein, Andreas C; Morgan, Donald A; Frommolt, Peter; Brinkkötter, Paul T; Hammerschmidt, Philipp; Benzing, Thomas; Rahmouni, Kamal; Wunderlich, F Thomas; Kloppenburg, Peter; Brüning, Jens C.

Cell; 165(1): 125-138, 2016 Mar 24.

Artículo en Inglés | MEDLINE | ID: mdl-27015310

3.

Hypothalamic UDP Increases in Obesity and Promotes Feeding via P2Y6-Dependent Activation of AgRP Neurons.

Steculorum, Sophie M; Paeger, Lars; Bremser, Stephan; Evers, Nadine; Hinze, Yvonne; Idzko, Marco; Kloppenburg, Peter; Brüning, Jens C.

Cell; 162(6): 1404-17, 2015 Sep 10.

Artículo en Inglés | MEDLINE | ID: mdl-26359991

4.

Die another day: a painless path to longevity.

Steculorum, Sophie M; Brüning, Jens C.

Cell; 157(5): 1004-6, 2014 May 22.

Artículo en Inglés | MEDLINE | ID: mdl-24855937

5.

Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding.

Vogt, Merly C; Paeger, Lars; Hess, Simon; Steculorum, Sophie M; Awazawa, Motoharu; Hampel, Brigitte; Neupert, Susanne; Nicholls, Hayley T; Mauer, Jan; Hausen, A Christine; Predel, Reinhard; Kloppenburg, Peter; Horvath, Tamas L; Brüning, Jens C.

Cell; 156(3): 495-509, 2014 Jan 30.

Artículo en Inglés | MEDLINE | ID: mdl-24462248

6.

Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity.

Jais, Alexander; Solas, Maite; Backes, Heiko; Chaurasia, Bhagirath; Kleinridders, André; Theurich, Sebastian; Mauer, Jan; Steculorum, Sophie M; Hampel, Brigitte; Goldau, Julia; Alber, Jens; Förster, Carola Y; Eming, Sabine A; Schwaninger, Markus; Ferrara, Napoleone; Karsenty, Gerard; Brüning, Jens C.

Cell; 166(5): 1338-1340, 2016 Aug 25.

Artículo en Inglés | MEDLINE | ID: mdl-27565353

7.

Preserved striatal innervation maintains motor function despite severe loss of nigral dopaminergic neurons.

Paß, Thomas; Ricke, Konrad M; Hofmann, Pierre; Chowdhury, Roy S; Nie, Yu; Chinnery, Patrick; Endepols, Heike; Neumaier, Bernd; Carvalho, André; Rigoux, Lionel; Steculorum, Sophie M; Prudent, Julien; Riemer, Trine; Aswendt, Markus; Liss, Birgit; Brachvogel, Bent; Wiesner, Rudolf J.

Brain; 2024 Apr 04.

Artículo en Inglés | MEDLINE | ID: mdl-38574200

8.

AgRP neuronal activity across feeding-related behaviours.

Gouveia, Ayden; de Oliveira Beleza, Rui; Steculorum, Sophie M.

Eur J Neurosci; 54(10): 7458-7475, 2021 11.

Artículo en Inglés | MEDLINE | ID: mdl-34655481

9.

The paradox of neuronal insulin action and resistance in the development of aging-associated diseases.

Steculorum, Sophie M; Solas, Maite; Brüning, Jens C.

Alzheimers Dement; 10(1 Suppl): S3-11, 2014 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-24529522

10.

Circulating uridine dynamically and adaptively regulates food intake in humans.

Hanssen, Ruth; Rigoux, Lionel; Albus, Kerstin; Kretschmer, Alina Chloé; Edwin Thanarajah, Sharmili; Chen, Weiyi; Hinze, Yvonne; Giavalisco, Patrick; Steculorum, Sophie M; Cornely, Oliver A; Brüning, Jens C; Tittgemeyer, Marc.

Cell Rep Med; 4(1): 100897, 2023 01 17.

Artículo en Inglés | MEDLINE | ID: mdl-36652907

11.

CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice.

Hammerschmidt, Philipp; Steculorum, Sophie M; Bandet, Cécile L; Del Río-Martín, Almudena; Steuernagel, Lukas; Kohlhaas, Vivien; Feldmann, Marvin; Varela, Luis; Majcher, Adam; Quatorze Correia, Marta; Klar, Rhena F U; Bauder, Corinna A; Kaya, Ecem; Porniece, Marta; Biglari, Nasim; Sieben, Anna; Horvath, Tamas L; Hornemann, Thorsten; Brodesser, Susanne; Brüning, Jens C.

Nat Commun; 14(1): 7824, 2023 Nov 29.

Artículo en Inglés | MEDLINE | ID: mdl-38016943

12.

Sweet Mitochondrial Dynamics in VMH Neurons.

Steculorum, Sophie M; Brüning, Jens C.

Cell Metab; 23(4): 577-9, 2016 Apr 12.

Artículo en Inglés | MEDLINE | ID: mdl-27076074

13.

Neonatal ghrelin programs development of hypothalamic feeding circuits.

Steculorum, Sophie M; Collden, Gustav; Coupe, Berengere; Croizier, Sophie; Lockie, Sarah; Andrews, Zane B; Jarosch, Florian; Klussmann, Sven; Bouret, Sebastien G.

J Clin Invest; 125(2): 846-58, 2015 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-25607843

14.

Perinatal programming of metabolic diseases: role of insulin in the development of hypothalamic neurocircuits.

Steculorum, Sophie M; Vogt, Merly C; Brüning, Jens C.

Endocrinol Metab Clin North Am; 42(1): 149-64, 2013 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-23391245

15.

Neuronal control of peripheral insulin sensitivity and glucose metabolism.

Ruud, Johan; Steculorum, Sophie M; Brüning, Jens C.

Nat Commun; 8: 15259, 2017 05 04.

Artículo en Inglés | MEDLINE | ID: mdl-28469281

16.

Maternal diabetes compromises the organization of hypothalamic feeding circuits and impairs leptin sensitivity in offspring.

Steculorum, Sophie M; Bouret, Sebastien G.

Endocrinology; 152(11): 4171-9, 2011 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-21862611

17.

Developmental effects of ghrelin.

Steculorum, Sophie M; Bouret, Sebastien G.

Peptides; 32(11): 2362-6, 2011 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-21736909

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Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity.

AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue.

Hypothalamic UDP Increases in Obesity and Promotes Feeding via P2Y6-Dependent Activation of AgRP Neurons.

Die another day: a painless path to longevity.

Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding.

Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity.

Preserved striatal innervation maintains motor function despite severe loss of nigral dopaminergic neurons.

AgRP neuronal activity across feeding-related behaviours.

The paradox of neuronal insulin action and resistance in the development of aging-associated diseases.

Circulating uridine dynamically and adaptively regulates food intake in humans.

CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice.

Sweet Mitochondrial Dynamics in VMH Neurons.

Neonatal ghrelin programs development of hypothalamic feeding circuits.

Perinatal programming of metabolic diseases: role of insulin in the development of hypothalamic neurocircuits.

Neuronal control of peripheral insulin sensitivity and glucose metabolism.

Maternal diabetes compromises the organization of hypothalamic feeding circuits and impairs leptin sensitivity in offspring.

Developmental effects of ghrelin.